| Date | Game | Location | Time |
| 02/12/10 | Duke 16, Denver 6 | Durham, N.C. | Recap |
| 02/13/10 | Drexel 13, Virginia Tech 9 | Blacksburg, Va. | Recap |
| 02/14/10 | Duke 19, Vanderbilt 10 | Nashville, Tenn. | Recap | Gametracker |
| North Carolina 18, Denver 7 | Chapel Hill, N.C. | Recap | |
| Maryland 17, Richmond 7 | College Park, Md. | Recap | |
| 02/19/10 | Duke 17, Richmond 9 | Richmond, Va. | Recap |
| North Carolina 12, Vanderbilt 6 | Chapel Hill, N.C. | Recap | |
| 02/20/10 | Boston College 20, Bryant 4 | Smithfield, R.I. | Recap |
| Loyola 15, Virginia 11 | Charlottesville, Va. | Recap | |
| Virginia Tech 19, Presbyterian 5 | Blacksburg, Va. | Recap | |
| 02/21/10 | Duke 16, William & Mary 9 | Williamsburg, Va. | Recap |
| Maryland 17, Penn State 9 | University Park, Pa. | Recap | Gametracker | |
| North Carolina 19, Richmond 7 | Richmond, Va. | Recap | |
| 02/24/10 | James Madison 16, Virginia Tech 3 | Harrisonburg, Va. | Recap |
| Virginia 17, Richmond 8 | Charlottesville, Va. | Recap | |
| 02/26/10 | Boston College 14, Canisius 5 | Chestnut Hill, Mass. | |
| North Carolina 22, Oregon 5 | Chapel Hill, N.C. | ||
| 02/27/10 | Maryland 17, Duke 4 | Durham, N.C. | Recap |
| Virginia 14, Syracuse 13 | Charlottesville, Va. | Recap | |
| George Mason 11, Virginia Tech 7 | Fairfax, Va. | Recap | Gametracker | |
| 02/28/10 | North Carolina 18, Florida 5 | Chapel Hill, N.C. | Recap |
| 03/02/10 | Boston College 18, Jacksonville 6 | Jacksonville, Fla. | Recap |
| 03/05/10 | Maryland 11, Virginia 5 | College Park, Md. | Recap | Gametracker |
| 03/06/10 | Boston College 20, Siena 5 | Chestnut Hill, Mass. | Recap |
| Duke 13, Princeton 6 | Princeton N.J. | Recap | |
| North Carolina 11, Penn 6 | Chapel Hill, N.C. | Recap | |
| 03/07/10 | George Washington 9, Virginia Tech 8 | Washington, D.C. | Recap | Gametracker |
| Virginia 13, Penn State 8 | University Park, Pa. | Recap | Gametracker | |
| 03/09/10 | Maryland 16, George Mason 4 | Fairfax, Va. | Gametracker |
| 03/10/10 | Duke 10, Boston University 6 | Durham, N.C. | Recap |
| 03/11/10 | Virginia Tech 16, CCSU 4 | New Britain, Conn. | Recap |
| 03/13/10 | New Hampshire @ Maryland | College Park, Md. | 12:00 PM Gametracker |
| Georgetown @ Duke | Durham, N.C. | 1:00 PM | |
| North Carolina @ Virginia | Charlottesville, Va. | 1:00 PM | |
| Virginia Tech @ Boston College | Chestnut Hill, Mass. | 1:00 PM Gametracker | |
| 03/17/10 | Duke @ Virgnia Tech | Blacksburg, Va. | 4:00 PM |
| Boston College @ Holy Cross | Worcester, Mass. | 4:30 PM | |
| Georgetown @ Maryland | College Park, Md. | 7:00 PM Gametracker | |
| Virginia @ William & Mary | Williamsburg, Va. | 7:00 PM | |
| 03/20/10 | Boston College @ Maryland | College Park, Md. | 12:00 PM Gametracker |
| North Carolina @ Georgetown | Washington, D.C. | 1:00 PM Gametracker | |
| 03/21/10 | Navy @ Duke | Durham, N.C. | 1:00 PM |
| 03/24/10 | Davidson @ Virginia Tech | Blacksburg, Va. | 4:00 PM |
| Vermont @ Boston College | Chestnut Hill, Mass. | 4:00 PM Gametracker | |
| James Madison @ Virginia | Charlottesville, Va. | 7:00 PM | |
| 03/25/10 | Stanford @ Maryland | College Park, Md. | 7:00 PM Gametracker |
| 03/27/10 | North Carolina @ Boston College | Chestnut Hill, Mass. | 12:00 PM Gametracker |
| Virginia @ Duke | Durham, N.C. | 1:00 PM | |
| Virginia Tech @ Old Dominion | Norfolk, Va. | 1:00 PM Gametracker | |
| Maryland @ James Madison | Harrisonburg, Va. | 4:00 PM Gametracker | |
| 03/31/10 | Old Dominion @ Virginia | Charlottesville, Va. | 7:00 PM |
| Towson @ Maryland | College Park, Md. | 7:00 PM Gametracker | |
| 04/02/10 | Virginia Tech @ North Carolina | Chapel Hill, N.C. | 4:00 PM Gametracker |
| Maryland @ Penn | Philadelphia, Pa. | 7:00 PM | |
| 04/03/10 | Northwestern @ Duke | Durham, N.C. | 12:00 PM |
| Boston College @ Virginia | Charlottesville, Va. | 1:00 PM | |
| 04/04/10 | Davidson @ Duke | Durham, N.C. | 12:00 PM |
| North Carolina @ Old Dominion | Norfolk, Va. | 1:00 PM Gametracker | |
| 04/05/10 | Harvard @ Virginia | Charlottesville, Va. | 7:00 PM |
| 04/07/10 | Iona @ Boston College | Chestnut Hill, Mass. | 4:00 PM Gametracker |
| Virginia @ Virginia Tech | Blacksburg, Va. | 4:00 PM | |
| 04/10/10 | Maryland @ North Carolina | Chapel Hill, N.C. | 11:00 AM Gametracker |
| American @ Virginia Tech | Durham, N.C. | 1:00 PM | |
| Boston College @ Duke | Durham, N.C. | 1:00 PM | |
| 04/13/10 | George Mason @ Virginia | Charlottesville, Va. | 7:00 PM |
| 04/14/10 | Virginia Tech @ Longwood | Farmville, Va. | 4:00 PM |
| Boston College @ Boston University | Boston, Mass. | 6:00 PM | |
| Duke @ North Carolina | Chapel Hill, N.C. | 7:00 PM | |
| Maryland @ Princeton | Princeton, N.J. | 7:00 PM | |
| 04/17/10 | Virginia Tech @ Maryland | College Park, Md. | 12:00 PM |
| 04/18/10 | Boston College @ Brown | Providence, R.I. | 1:00 PM |
| North Carolina @ Northwestern | Evanston, Ill. | 1:00 PM |
