Boston College held large advantages in total yards (400-67), first downs (21-5) and time of possession (43:07-16:53).
The Eagles' defense held Buffalo to 26 rushing yards and a 1-for-11 third down conversion rate.
The defense was led by sophomore DT Ray Smith and senior DB John Johnson who both had five tackles.
Junior DB Isaac Yiadom had a game-high three pass breakups.
Graduate student QB Patrick Towles finished 14-for-25 for a season-high 234 yards, two touchdowns and no interceptions.
Redshirt freshman RB Davon Jones rushed 14 times for 53 yards and his first career touchdown.
Sophomore RB Jon Hilliman added 54 yards on 19 carries.
Sophomore WR Jeff Smith led the receivers with five catches for 65 yards.
Boston College scored the first 14 points of the game and led the rest of the way. Jones scored first with a one-yard rush and Towles found junior WR Charlie Callinan for a seven-yard score in the second quarter.
HOW IT HAPPENED
Boston College struck first with a touchdown with 35 seconds left in the first quarter. Towles hit redshirt freshman WR Chris Garrison for a 44-yard pass and Jones finished the drive from the one on a pitch play to the left.
The Eagles scored on their next drive to increase the lead to 14-0 with 9:25 left in the second. It was an 11-play, 54-yard drive capped by a Towles seven-yard touchdown pass to Callinan.
Buffalo's Ishmael Hargrove blitzed through the middle on a BC 3rd-and-6 and got to Towles, stripping him and recovering the fumble on the Eagles' 11-yard line. The Bulls turned that into three points when Adam Mitcheson hit a 28-yard field goal midway through the second.
BC made it a 21-3 game just before the half when Towles connected with sophomore WR Michael Walker for an 11-yard touchdown to cap an 11-play, 84-yard drive that lasted 6:07.
The Eagles tacked on another touchdown with 9:40 left in the game to push the lead to 28-3. Hilliman rushed seven times and Smith caught a 43-yard pass in the eight-play drive, which Hilliman finished with a one-yard run.
Sophomore RB Richard Wilson finished the BC scoring late in the fourth with a three-yard touchdown rush.
The Eagles return to Alumni Stadium next Friday, Oct. 7, when they host No. 5 Clemson at 7:30 p.m. ESPN has the broadcast and it will be streamed on WatchESPN and carried on the radio by the Boston College IMG Sports Network, including WEEI 93.7 FM locally.